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Date : 1995-05-01
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DNA Repair and Mutagenesis 9781555813192 Medicine ~ • Discussed the field within a strong historical framework and all aspects of biological responses to DNA damage are detailed • Provides information on covering sources and consequences of DNA damage correcting altered bases in DNA DNA repair DNA damage tolerance and mutagenesis regulatory responses to DNA damage in eukaryotes and disease states associated with defective biological responses to DNA damage
Mutagenesis and DNA repair ~ DNA damage must be kept in check in order for an organism to be viable through DNA repair mechanisms If mutations survive without being corrected they can be passed down to future generations change the function of proteins and cause cancer
Mechanisms of DNA damage repair and mutagenesis ~ However robust DNA repair and damagebypass mechanisms faithfully protect the DNA by either removing or tolerating the damage to ensure an overall survival Deviations in this finetuning are known to destabilize cellular metabolic homeostasis as exemplified in diverse cancers where disruption or deregulation of DNA repair pathways results in genome instability
DNA Repair and Mutagenesis Wikipedia ~ DNA Repair and Mutagenesis is a collegelevel textbook about DNA repair and mutagenesis written by Errol Friedberg Graham Walker Wolfram Siede Richard D Wood and Roger Schultz In its second edition as of 2009 DNA Repair and Mutagenesis contains over 1000 pages 10000 references and 700 illustrations and has been described as the most comprehensive book available in the field
DNA Repair and Mutagenesis Carnegie Ecology ~ 3 DNA Repair and Mutagenesis 31 STATE OF KNOWLEDGE Coping with genetic injury caused by environmental agents all living organisms are equipped with an intricate network of repair processes
DNA Mutation and Repair ~ DNA Mutation and Repair A mutation which may arise during replication andor recombination is a permanent change in the nucleotide sequence of DNA Damaged DNA can be mutated either by substitution deletion or insertion of base pairs Mutations for the most part are harmless except when they lead to cell death or tumor formation
DNA Repair Journal Elsevier ~ DNA Repair provides a forum for the comprehensive coverage of DNA repair and cellular responses to DNA damage The journal publishes original observations on genetic cellular biochemical structural and molecular aspects of DNA repair mutagenesis cell cycle regulation apoptosis and other biological responses in cells exposed to genomic insult as well as their relationship to human disease
DNA repair Wikipedia ~ As well as mutations to DNA damage repair genes mutations also arise in the genes responsible for arresting the cell cycle to allow sufficient time for DNA repair to occur and some genes are involved in both DNA damage repair and cell cycle checkpoint control for example ATM and checkpoint kinase 2 CHEK2 – a tumor suppressor that is often absent or downregulated in nonsmall cell lung cancer
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